Seminom HE

seminoma ICD-10: C62.9; ICD-O: 9061/3

Klinik: Mann 38J.; schmerzlose Hodenvergrösserung links; Tumormarker unauffällig; sonographisch homogenes Bild.
 
Morphologie:

Seminom
- septierte Tumorknoten
- grosse rundliche Tumorzellen
      helles PAS-positives Zytoplasma (Glykogen)
      grobes Chromatin
      deutliche Nukleolen
      positiv für plazentare alkalissche Phosphatase (PLAP)
- eingestreute Lymphozyten / Plasmazellen
 
Intratubuläre Keimzellneoplasie in benachbarten Tubuli seminiferi
- gestörte Spermatogenese
- vergrösserte Keimzellen (vgl. Seminomzellen)
 

38-year-old male; painless enlargement of the left testicle; tumour markers unremarkable; ultrasound shows homogenous picture.

Morphology:

Seminoma
- Septated tumour cells
- Large round tumour cells showing the following:
      Light shaded PAS positive cytoplasm (glycogen)
      Coarse chromatin
      Distinct nucleoli
      Positive for placental alkalising phosphatase (PLAP)
- Interspersed lymphocytes/plasma cells

Intratubular germ cell neoplasia in neighbouring seminiferous tubules
- Disturbed spermatogenesis
- Enlarged germ cells, comparable with seminoma cells (see Seminomzellen)